Retail & E-commerce Businesses for Sale in San Diego, CA

This national direct-to-consumer food brand serves affluent, repeat customers through premium products, direct sourcing relationships, and established digital marketing infrastructure. Its large customer database, high average order values, and reported cash flow provide a foundation for continued growth in specialty food e-commerce.

This franchise retail service business combines shipping, printing, mailbox, and document services in one convenient location. It offers a diversified revenue mix, repeat customer traffic, and an operational structure that can suit an owner seeking a manageable semi-absentee business.

This pharmacy combines retail prescription volume with a higher-margin compounding segment, creating a mixed-revenue model with attractive economics. It may appeal to buyers seeking a well-established healthcare retail business with strong margins and long-term neighborhood demand in Southern California.

This consumer products business sells natural skincare items through retail and direct channels, supported by a lean operating model. It may appeal to a buyer looking for a branded product company with repeat-purchase potential and room to expand distribution in California.

A long-tenured upscale apparel retailer in San Diego specializing in custom-made men's suits and shirts using a proprietary measuring methodology, complemented by ready-to-wear offerings for both genders. The business has served a loyal clientele of local residents and tourists for decades from a single location, demonstrating resilience and consistent demand in the premium clothing segment. The proprietary custom fitting approach creates a differentiated product that is difficult for online or mass-market competitors to replicate.

This franchised convenience store in the San Diego metro area operates under a nationally recognized brand, generating consistent cash flow from a diverse mix of consumable products, food, and beverages catering to on-the-go customers. The franchise model provides operational systems, brand recognition, and supplier relationships that reduce execution risk for a new owner. Consistent revenue and a high-traffic location in one of California's largest metro markets underpin the business's near-term earnings stability.

This high-end specialty sports and active lifestyle retail boutique has operated for nearly five decades, building a loyal multigenerational customer base through expert product knowledge, premium brand selection, and exceptional in-store service. The business serves individuals, children, and families seeking performance gear and lifestyle products not typically available at mass-market retailers. Decades of brand equity and deep customer relationships provide a durable competitive moat for a buyer entering the specialty athletic retail space.

This established franchise floral shop operates from a spacious retail location in the San Diego area, serving both a local repeat customer base and significant tourist demand. The business generates approximately $800,000 in annual gross sales with attractive discretionary earnings, supported by a recognized national franchise brand. All fixtures and inventory are included, enabling an owner-operator to step in immediately.