Businesses for Sale in St. Louis, MO

This long-standing personal-services business benefits from strong brand recognition, loyal clientele, and a trained team. Its modern facility, consistent revenue, and potential financing flexibility may appeal to an entrepreneur or investor seeking a turnkey operation in Missouri.

This staffing and HR services business offers a diversified mix of temporary, contract, direct-hire, and flexible placement services. It may appeal to a buyer seeking a turnkey professional services operation with recurring demand, supported by trained staff and franchisor training and marketing resources in the St. Louis region.

This staffing and HR services business provides temporary, contract, direct-hire, and flexible placement solutions to local employers and job seekers. It may suit a buyer looking for a turnkey professional services operation with trained staff, franchisor support, and a business model tied to recurring workforce demand in the St. Louis region.

This route-based snack distribution business offers recurring retail stops and a familiar consumer staples product mix. It may appeal to buyers seeking a proven local distribution operation with steady sales in Missouri.

This restaurant and bar benefits from strong annual sales, a recognizable position in a desirable business district, and a long-standing customer base. The business may appeal to a buyer seeking a proven hospitality asset with scale and visibility in the St. Louis region.

This waste-services business serves commercial, residential, and restoration customers with a substantial equipment base already in place. Buyers may value the recurring contractor demand, professional management structure, and expansion potential into adjacent services.

This independent hardware store combines everyday retail demand with the added value of included real estate. Its long operating history and loyal neighborhood customer base suggest durable repeat traffic and stable owner-operator appeal in the St. Louis region.

This restaurant and bar offers a full-service food-and-beverage model with room for additional revenue through catering and related channels. The established staff and recognizable neighborhood appeal may interest buyers in the St. Louis region.

This wholesale distribution company serves multiple trade segments with a broad product line and long-standing supplier relationships. The business may appeal to buyers looking for recurring B2B demand, diversified customer relationships, and a durable regional operating platform.

This route-based logistics business offers immediate cash flow through a clustered set of delivery routes with vehicles and drivers already in place. It may appeal to a buyer looking for a semi-absentee transportation operation with established systems and strong earnings.

This accounting practice offers recurring tax, accounting, and consulting work supported by experienced staff and a loyal client base. Stable year-round demand and a strong fee structure may appeal to buyers seeking a predictable professional services business.

This automotive business combines vehicle sales with repair services, giving it more than one revenue stream within the same operation. A buyer may value the established local reputation, service demand, and room for growth on a modest footprint in a Midwest state.

This hospitality property offers a straightforward lodging business with existing operations and guest amenities in a major regional market. It may appeal to an investor or operator seeking a value-oriented asset with room for operational improvement.

This medical practice uses a walk-in model that combines urgent care and primary care services, creating steady daily patient traffic. It may appeal to a buyer seeking a healthcare business with recurring demand, operational efficiency, and room for expansion in the St. Louis area.

This outpatient behavioral health practice offers recurring client demand and multiple potential service expansion paths, which can support growth without starting from zero. It may appeal to a buyer looking for a boutique healthcare business with a trusted reputation in Missouri.

This residential concrete franchise provides a turnkey service business with existing crews, booked work, and reduced overhead from a home-based structure. The recognized brand and financing options may appeal to buyers seeking an entry into the construction trades in Missouri.

A high-volume grocery store in the St. Louis metro area generating $400,000 in monthly sales and an additional $10,000 per month in gaming income, currently operated under absentee ownership. The store holds a gaming license and benefits from limited local competition, supporting above-average margins in a market with strong consumer demand. The existing absentee ownership model suggests meaningful earnings upside under active management.

This three-unit specialty cookie franchise platform in the greater St. Louis market generated approximately $3.52 million in combined 2025 revenue, supported by a full-time Area Manager and experienced store-level teams across high-growth suburban locations. The business operates additional contracted revenue from a professional sports venue partnership, diversifying income beyond traditional retail foot traffic. Comprehensive operating systems and economies of scale across labor and purchasing create a scalable foundation well-suited for further unit expansion.

A full-service custom parts manufacturing business in the St. Louis metro area with decades of continuous operation, a seasoned production manager with 30-plus years of tenure, and a 36,000-square-foot facility with real estate included in the purchase price. The retiring founder's exit creates a rare opportunity to acquire a proven industrial manufacturer with an entrenched customer base and day-one revenue. The facility's owned real estate provides both operational stability and a meaningful asset floor for the acquisition.

This mobile environmental testing business serves B2B clients across renovation, demolition, insurance, and disaster recovery sectors in the Midwest, generating demand that is largely regulation-driven and non-discretionary. With a diversified customer base across multiple industries, the business model is insulated from single-sector downturns and operates on a Monday-through-Friday schedule with a small, stable team. The acquisition offers a new owner a systemized operation with built-in recurring demand and meaningful growth potential through expanded client development.

A multi-unit baked goods franchise portfolio in the St. Louis metro area ranking among the top-performing locations both regionally and nationally within its franchise system. The portfolio generated over $900K in SDE in 2025 with management in place, supporting a semi-absentee ownership model for a qualified buyer. Top-quartile unit economics and a proven franchise operating system make this a compelling platform acquisition in the food and beverage segment.

This two-location full-service auto repair business in the St. Louis metro operates with experienced managers in place at each facility, enabling semi-absentee ownership for an investor or multi-unit operator. Both sites benefit from high-visibility locations, strong online ratings, and long-tenured certified technicians, supporting consistent repeat business and community reputation. Optional real estate purchase at each location adds further asset value for a buyer seeking ownership of the underlying property.

This regional trucking company has operated in the St. Louis market for over two decades, building a reputation for reliability with a loyal customer base and well-maintained equipment fleet. An experienced team is in place to ensure continuity through a transition, and the current owner is committed to supporting the handoff process. Pre-approved SBA financing lowers the capital barrier for qualified buyers seeking a proven logistics platform.

A fully staffed psychiatric and mental health practice in the St. Louis metro generating approximately $739K in annual cash flow, supported by an experienced team of therapists, nurse practitioners, and administrative staff. The full operational team in place ensures continuity of care and reduces transition risk for an incoming owner. This type of mental health platform is difficult to build from scratch given licensing requirements, staff credentialing, and patient trust — making an established acquisition an attractive entry strategy.